In 1977, Sanger developed a much simpler sequencing method, called “chain termination,” which is today known simply as Sanger sequencing. This technique took advantage of a different type of special nucleotide called a dideoxyribonucleotide, or ddNTP. ddNTPs lack one of the hydroxyl groups present on a normal dNTP, preventing the chemical reaction necessary to add another nucleotide and terminating DNA elongation.
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Now, let me be clear: complexity is sometimes the right call. If you’re processing millions of transactions, you might need distributed systems. If you have 10 teams working on the same product, you probably need service boundaries. When the problem is complex, the solution (probably) should be too!
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